What is Hydroxypropyl Methylcellulose?

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Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery

Published in Drug Delivery, 2023

Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu, Hong-Liang Lin

Hyaluronic acid (HA) can relieve irritation, moisturize the ocular surface, and overcome the sodium hyaluronate deficiency in the tear film, thus alleviating DED symptoms. Hence, HA is the main ingredient in artificial tear formulations currently used for treating DED and Sjögren’s syndrome (Yang et al., 2021). Moreover, the mucoadhesive property and high viscosity of HA (Sudha & Rose, 2014) prevents the rapid washout of the drug by tears, thus prolonging the residence of drug and increasing ocular drug availability (Salwowska et al., 2016). Besides, the high molecular weight (MW) of HA inhibits inflammation by suppressing the production of inflammatory cytokines (Ruppert et al., 2014), which is beneficial for DED (Yamaguchi, 2018). The advantages of the cellulose derivatives of hydroxypropyl methylcellulose (HPMC) include safety, biocompatibility, and mucoadhesive property, which make them suitable for use as ODDS. Moreover, the mucoadhesive property of HPMC enables long contact time, allowing the drug to easily permeate the eye tissue (Tundisi et al., 2021). Therefore, we hypothesize that the addition of HPMC and HA would convert nongellable P407 aqueous solution into an in-situ gellable hydrogel with enhanced mucoadhesive characteristics. Accordingly, we developed P407-based thermosensitive in-situ hydrogels combined with HPMC and HA to reduce the desired concentration of P407 required for maintaining the formation of in-situ hydrogels with an enhanced mucoadhesive property to increase residence time for the continuing ocular delivery of solubilized testosterone in this study.

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Nanocrystals for controlled delivery: state of the art and approved drug products

Published in Expert Opinion on Drug Delivery, 2022

Rahul S. Kalhapure, Siddhant Palekar, Ketan Patel, Jasmin Monpara

Nanocrystals for transdermal controlled delivery have been reported in the literature by combining them with another carrier system (Table 4). Diosmin (DM) is a flavonoid having antiulcer, anti-inflammatory, anticancer activities and primarily used in diabetic ulcers. Similar to all other flavonoid, DM is practically insoluble in water. Atia et al developed diosmin nanocrystals (DM-NCs) loaded alginate wafers. Initially, nanosuspension was prepared using DMSO as a solvent and water as an antisolvent. Hydroxypropyl methylcellulose (HPMC) and/or microcrystalline cellulose (MC) were added as stabilizer to the suspension in 1:1 ratio. DM-NCs loaded wafers/gel were evaluated for treatment of induced diabetes and ulcers in mice. It was observed that at day 6, wound closure in wafers, gels and neat DM was 70.7%, 59.66% and 28.13%, respectively. The authors found that using sodium alginate and gelatin (1:1) wafers loaded with nanocrystals provided a sustained release of diosmin over 8 h [54]. Authors have performed lyophilization of nanosuspension to increase stability however, no stability data for extended storage at different conditions has been provided.

Design and evaluation of glimepiride hydrogel for transdermal delivery

Published in Drug Development and Industrial Pharmacy, 2022

Haiying Li, Jiajia Wang, Qianru Xu, Shuya Tian, Wenzhi Yang

Many naturally existing and synthetic materials, such as gelatin, carbopol, polyvinyl alcohol (PVA) and cellulose derivatives, can be used as hydrogel matrix [14]. Hydroxypropyl methylcellulose (HPMC) has been widely employed in the pharmaceutical industry because of its nontoxicity, good biocompatibility, film-forming capability and biodegradability [10,15]. The blend system of HPMC and other materials has superior properties [16,17]. Pullulan (Pu) is an extracellular microbial polysaccharide, which possesses good aqueous solubility, high adhesion and distinct film-forming ability [17]. In addition, Pu shows excellent biocompatibility and mechanical properties and has been approved by FDA for a wide application in the food and pharmaceutical industries [18]. Therefore, HPMC and Pu were chosen as combined matrices based on their good activity, and they were mixed physically to form transparent hydrogel with film-forming properties.

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